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Alternating electric field therapy
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Alternating Electric Field Therapy (sometimes called Tumor Treating Fields, abbreviated as TTF or TTFields) is a type of electromagnetic field therapy using low-intensity electrical fields to treat cancer.〔(【引用サイトリンク】title=NCCN Guidelines for CNS cancers )〕 A TTF-generating device manufactured by the Israeli company Novocure is approved in the United States and Europe for the treatment of recurrent glioblastoma multiforme (GBM), and is undergoing clinical trials for several other tumor types.〔(【引用サイトリンク】url=https://clinicaltrials.gov/ct2/results?term=novocure&Search=Search )〕 Despite earning regulatory approval, the efficacy of this technology remains controversial among medical experts.〔
==Proposed biological mechanism==
Alternating electric field therapy / TTF was initially described in 2004 as the use of insulated electrodes to apply very-low-intensity, intermediate-frequency alternating electrical fields to a target area containing proliferating cells. In preclinical cancer models, TTF appeared to show selective toxicity to proliferating cells through an antimitotic mechanism.〔〔〔 In principle, this approach could be selective for cancer cells in regions of the body, such at the brain, where the majority of normal cells are non-proliferating.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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